How long does an increase in an SSRI (specifically Zoloft) take to work? I've been on Zoloft for about 6 years, and I recently upped it to 75mg, and then we upped it to 100mg about 2 weeks ago. I'm still experiencing obsessive thoughts and derealization and over-thinking, and I'm just getting real nervous that it won't ever leave. My question is, anyone who has had any success with any SSRI, how long did it take to work? And what was your whole experience getting used to it like? Thank you all so much!![]()