I'm sorry to hear that, Kirk. Depression can easily take its hold during these tough times. Yeah, meds aren't enough, he needs to (either through therapy or deep introspection) get in touch with the root cause(s) of the depression. If he get easily mad it makes it hard to reach out and offer advise. I hope you will find the words to get through to him.
That being said.. I also struggle want to go out, and I'm still dealing with a bit of Derealization that I can't shake off. But considering the state of the word, I'd bet I"m not alone; but pills can't fix that.