What you say abot serotonin and SSRIs certainly sheds ALOT of light on the problem with them. As you say, either too much serotonin OR not enough of it can cause anxiety problems. But if your have a problem with too much serotonin, SSRIs are going to exacerbate the problem. This is probably a BIG reason why SO many people out there experience anxiety and obsessive thoughts from hell when they try to take SSRIs. Of course, even if your serotonin is generally LOW, SSRIs can be a problem. The problem here is that SSRIs increase levels of serotonin in the brain GLOBALLY, when fine tuning is likely what is needed.Originally Posted by joey9
Speaking of genetics and anxiety, some recent studies suggest that anxiety is perhaps less of a traditional genetic problem than an epigenetic problem. In other words, it is possible that anxiety is a problem of gene expression. Although gene expression in humans is not yet very well understood, it IS known that gene expression can be influenced by MANY things. For instance, nutritional deficiencies could possibly change gene expression in an attempt to help nutritionally deprived people survive. And if this means, say, making cuts to serotonin production in order to conserve tryptophan or vitamin B6, problems like depression and anxiety could result. Of course, brain operation (ie thoughts) could also possibly affect gene expression, which could result in longer term changes as a result of those thoughts. Thus, correcting nutritional deficiencies and negative thoughts could in some manner work at least partially by correcting epigenetic problems. Of course, much of what I am saying here is conjecture, as this is not well understood. But these are possibilities. And the fact that anxiety disorder IS correctable, although recovery tends to be slow and difficult tends to point to an epigenetic problem.